This 3D printed protein model of EGFR Active Mutant Tyrosine Kinase (TK) visualizes the impact of T790M/L858R mutations on the Active Loop of TK. The protein is in its active state, evident by the downward position of the active loop (orange), allowing for ATP to travel deep into its binding pocket. Bound to this binding pocket is TAK-285 (colored by atom type). This protein model is colored to visualize the atomic temperature and 3d printed in full-color sandstone.
