This 3D printed protein model of Apaf-1 Caspase 9 visualized as a volumetric surface. This biologic model is colored to visualize each chain's unique structure.
Protein Description
Mammalian intrinsic apoptosis requires activation of the initiator caspase-9, which then cleaves and activates the effector caspases to execute cell killing. The heptameric Apaf-1 apoptosome is indispensable for caspase-9 activation by together forming a holoenzyme. The molecular mechanism of caspase-9 activation remains largely enigmatic. Here, we report the cryoelectron microscopy (cryo-EM) structure of an apoptotic holoenzyme and structure-guided biochemical analyses.
Created from PDB ID: 5WVE.
