Bruton's Tyrosine Kinase 4OTF

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3D print of Bruton's Tyrosine Kinase in complex with small molecule inhibitor GDC-0834 created from PDB ID: 4OTF. The protein is colored according to the protein's bFactor, or atomic heat. Colored orange is the protein's active loop, a-loop, which displays an inactive conformation.

PubMed Abstract: 

SAR studies focused on improving the pharmacokinetic (PK) properties of the previously reported potent and selective Btk inhibitor CGI-1746 (1) resulted in the clinical candidate GDC-0834 (2), which retained the potency and selectivity of CGI-1746, but with much improved PK in preclinical animal models. Structure based design efforts drove this work as modifications to 1 were investigated at both the solvent exposed region as well as 'H3 binding pocket'.

For international customers outside the US, please visit the model on our 3D printing service's international website: LINK

Select the desired material finish and size below. Matte finish applies a UV protective, semi-glossy coating.