Curcumin is an ancient drug derived from turmeric and has been found to exhibit potent anticancer properties without clearl mechanisms of action. This 3D printed molecular model shows that curcumin is a highly potent and selective inhibitor of dual-specificity tyrosine-regulated kinase 2 (DYRK2), a cancer-causing kinase implicated in triple-negative breast cancer and multiple myeloma.
This is a 3D printed protein model of DYRK2 (dual-specificity tyrosine-regulated kinase 2) bound by Curcumin. This model visualizes the binding properties of Curcumin for DYRK2's (multi-colored from blue-white-red) by showcasing its hydrophobicity. Curcumin (colored by atom type) is tucked into the ATP binding pocket of DRYK2. Binding Curcumin tightly are DYRK2 residues Asp368 (green), Glu266 (blue), Lys251 (red). Held in place at the other end of Curcumin are the hydrophobic (red) DYRK2 residues mentioned below.
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Select the desired material finish and size below. Matte finish applies a UV protective, semi-glossy coating.
Created from PDB ID: 5ZTN