Curcumin is an ancient drug derived from turmeric and has been found to exhibit potent anticancer properties without clearl mechanisms of action. This 3D printed molecular model shows that curcumin is a highly potent and selective inhibitor of dual-specificity tyrosine-regulated kinase 2 (DYRK2), a cancer causing kinase implicated in triple-negative breast cancer and multiple myeloma.
This is a 3D printed protein model of DYRK2 (dual-specificity tyrosine-regulated kinase 2) bound by Curcumin. This model visualizes the binding properties of Curcumin (yellow-heteroatom type) for DYRK2's (white) by the identifying the three binding residues deep inside the ATP binding pocket, Asp368, Glu266, Lys251. Each residue is colored by heteroatom type. Model designed to pair with original PNAS publication: http://www.pnas.org/content/early/2018/07/05/1806797115
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Select the desired material finish and size below. Matte finish applies a UV protective, semi-glossy coating.
Created from PDB ID: 5ZTN