Ebola Virus Ectodomain

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This is a 3D print of the Ebola Virus Prefusion Ectodomain as seen on the virus plasma membrane. The protein surface is tinted green by the its "Hydrophobicity," or willingness to be around water molecules. To delineate the different chains, the GP2-Glycoprotein-plasma membrane are green colors. The model can be printed in a variety of materials and sizes. Please contact us to request.

Protein Description

Ebola virions contain a surface transmembrane glycoprotein (GP) that is responsible for binding to target cells and subsequent fusion of the viral and host-cell membranes. GP is expressed as a single-chain precursor that is posttranslationally processed into the disulfide-linked fragments GP1 and GP2. The GP2 subunit is thought to mediate membrane fusion. A soluble fragment of the GP2 ectodomain, lacking the fusion-peptide region and the transmembrane helix, folds into a stable, highly helical structure in aqueous solution. Limited proteolysis studies identify a stable core of the GP2 ectodomain. This 74-residue core, denoted Ebo-74, was crystallized, and its x-ray structure was determined at 1.9-A resolution. Ebo-74 forms a trimer in which a long, central three-stranded coiled coil is surrounded by shorter C-terminal helices that are packed in an antiparallel orientation into hydrophobic grooves on the surface of the coiled-coil.

For international customers outside the US, please visit the model on our 3D printing service's international website: LINK

Select the desired material finish and size below. Matte finish applies a UV protective, semi-glossy coating.

Created from PDB IDs: 3CSY, 2EBO.