EGFR Tyrosine Kinase Mutant 3W2O

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This 3D printed protein model of EGFR Active Mutant Tyrosine Kinase visuals the TK the impact of T790M/L858R mutations. The protein is in its active state, evident by the downward position of the active loop (orange), allowing for ATP to travel deep into its binding pocket. Bound to this binding pocket is TAK-285 (colored by atom type). This protein model is colored to visualize the atomic temperature and 3d printed in full-color sandstone.

Protein Description

The epidermal growth factor receptor (EGFR) family plays a critical role in vital cellular processes and in various cancers. Known EGFR inhibitors exhibit distinct antitumor responses against the various EGFR mutants associated with nonsmall-cell lung cancer. The L858R mutation enhances clinical sensitivity to gefitinib and erlotinib as compared with wild type and reduces the relative sensitivity to lapatinib. In contrast, the T790M mutation confers drug resistance to gefitinib and erlotinib. In these structures, M790 adopts distinct conformations to accommodate different inhibitors, whereas R858 allows conformational variations of the activation loop.

For international customers outside the US, please visit the model on our 3D printing service's international website: LINK

Select the desired material finish and size below. Matte finish applies a UV protective, semi-glossy coating, natural finish has no coating.

Created from PDB ID: 3W2O