H-Ras GTPase 3K8Y

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3D printed of H-Ras GTPase 3K8Y

Protein Description

Ras and its effector Raf are key mediators of the Ras/Raf/MEK/ERK signal transduction pathway. Mutants of residue Q61 impair the GTPase activity of Ras and are found prominently in human cancers. Yet the mechanism through which Q61 contributes to catalysis has been elusive. It is thought to position the catalytic water molecule for nucleophilic attack on the gamma-phosphate of GTP.

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Created from PDB ID: 3K8Y