HIV-1 Strand Transfer Complex Intasome 5U1C

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This is a 3D printed protein model of HIV-1 Strand Complex Intasome. Each chains A,C are colored light blue and chains B,D green. DNA backbone colored light grey and nucleotides by their base color. Biologic model is printed in full-color sandstone.

Protein Description

Like all retroviruses, HIV-1 irreversibly inserts a viral DNA (vDNA) copy of its RNA genome into host target DNA (tDNA). The intasome, a higher-order nucleoprotein complex composed of viral integrase (IN) and the ends of linear vDNA, mediates integration. Productive integration into host chromatin results in the formation of the strand transfer complex (STC) containing catalytically joined vDNA and tDNA. HIV-1 intasomes have been refractory to high-resolution structural studies. We used a soluble IN fusion protein to facilitate structural studies, through which we present a high-resolution cryo-electron microscopy (cryo-EM) structure of the core tetrameric HIV-1 STC and a higher-order form that adopts carboxyl-terminal domain rearrangements. The distinct STC structures highlight how HIV-1 can use the common retroviral intasome core architecture to accommodate different IN domain modules for assembly.

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Select the desired material finish and size below. Matte finish applies a UV protective, semi-glossy coating. Natural finish does not.

created from PDB ID: 5U1C