This is a 3D print of GLP-1 Analog (Victoza) in Complex with GLP-1 Receptor and visualized as a volumetric surface. 3D print of Victoza in Complex with GLP-1 Receptor created from PDB ID: 4ZGM.
The glucagon-like peptide-1 receptor (GLP-1R) belongs to Family B1 of the seven-transmembrane G protein-coupled receptors, and its natural agonist ligand is the peptide hormone glucagon-like peptide-1 (GLP-1). GLP-1 is involved in glucose homeostasis, and activation of GLP-1R in the plasma membrane of pancreatic beta-cells potentiates glucose-dependent insulin secretion. The N-terminal extracellular domain (nGLP-1R) is an important ligand binding domain that binds GLP-1 and the homologous peptide Exendin-4 with differential affinity. Victoza is a GLP-1 analog that stimulates the GLP-1 receptor in order to stimulate the release of insulin.
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